[Analysis of the effect of expanded non-invasive prenatal testing in prenatal screening population during pregnancy].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 38(11): 1041-1044, 2021 Nov 10.
Article
em Zh
| MEDLINE
| ID: mdl-34729739
ABSTRACT
OBJECTIVE:
To explore the clinical effect of expanded non-invasive prenatal testing (NIPT-plus) for prenatal screening.METHODS:
The screening result, prenatal diagnosis and pregnancy outcome of 3700 pregnant women who volunteered NIPT-plus screening at our center from September 2018 to December 2019 were reviewed.RESULTS:
Among the 3700 pregnant women, 74(2.0%) were scored positive for clinically significant fetal chromosomal abnormalities and underwent NIPT-plus screening. Sixty three women with a high risk underwent invasive prenatal diagnosis, among whom 19 were diagnosed, which yielded a positive predictive value (PPVs) of 30.2% (19/63). Statistical analysis showed that NIPT-plus has higher PPVs for common aneuploidies and low-to-medium PPVs for sex chromosome aneuploidies and microdeletion/microduplication syndromes.CONCLUSION:
As a screening technique, NIPT-plus has broader applications compared with conventional techniques, and has reference value for clinicians and pregnant women during pregnancy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Aneuploidia
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Female
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Humans
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China