Enantioselective analyses of chloroquine and hydroxychloroquine in rat liver microsomes through chiral liquid chromatography-tandem mass spectrometry.

Guo, Dong; He, Rujian; Su, Wenxia; Liang, Ziqing; Zhang, Weiguang; Fan, Jun

Guo, Dong; He, Rujian; Su, Wenxia; Liang, Ziqing; Zhang, Weiguang; Fan, Jun.

Afiliação

Guo D; School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, China.
He R; Guangzhou Research & Creativity Biotechnology Co. Ltd., Guangzhou, China.
Su W; School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, China.
Liang Z; School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, China.
Zhang W; School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, China.
Fan J; School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, China.

Chirality ; 34(1): 126-133, 2022 01.

Article em En | MEDLINE | ID: mdl-34736290

Assuntos

Hidroxicloroquina; Espectrometria de Massas em Tandem; Animais; Cloroquina; Cromatografia Líquida de Alta Pressão; Cromatografia Líquida; Microssomos Hepáticos; Ratos; Estereoisomerismo

Palavras-chave

LC-MS/MS chiral analysis; chloroquine; hydroxychloroquine; metabolism; rat liver microsomes

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Espectrometria de Massas em Tandem / Hidroxicloroquina Limite: Animals Idioma: En Revista: Chirality Assunto da revista: BIOLOGIA MOLECULAR / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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