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The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling.
Fazil, Mobashar Hussain Urf Turabe; Chirumamilla, Chandra Sekhar; Perez-Novo, Claudina; Wong, Brandon Han Siang; Kumar, Sunil; Sze, Siu Kwan; Vanden Berghe, Wim; Verma, Navin Kumar.
Afiliação
  • Fazil MHUT; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, Singapore.
  • Chirumamilla CS; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium.
  • Perez-Novo C; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium.
  • Wong BHS; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, Singapore; NTU Institute for Health Technologies (HealthTech NTU), Interdisciplinary Graduate Programme, Nanyang Technological University Singapore, Singapore.
  • Kumar S; Indian Council of Agricultural Research-National Bureau of Agriculturally Important Microorganisms, Kushmaur, Mau, Uttar Pradesh, India.
  • Sze SK; School of Biological Sciences, Nanyang Technological University Singapore, Singapore.
  • Vanden Berghe W; Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium. Electronic address: wim.vandenberghe@uantwerpen.be.
  • Verma NK; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, Singapore. Electronic address: nkverma@ntu.edu.sg.
J Biol Chem ; 297(6): 101377, 2021 12.
Article em En | MEDLINE | ID: mdl-34742736
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas Quinases / Linfócitos T / Transdução de Sinais / Movimento Celular / Proteína-Tirosina Quinase ZAP-70 / Vitanolídeos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura
Texto completo
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XML
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas Quinases / Linfócitos T / Transdução de Sinais / Movimento Celular / Proteína-Tirosina Quinase ZAP-70 / Vitanolídeos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura