The immunology of sepsis.
Immunity
; 54(11): 2450-2464, 2021 11 09.
Article
em En
| MEDLINE
| ID: mdl-34758337
ABSTRACT
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. This recently implemented definition does not capture the heterogeneity or the underlying pathophysiology of the syndrome, which is characterized by concurrent unbalanced hyperinflammation and immune suppression. Here, we review current knowledge of aberrant immune responses during sepsis and recent initiatives to stratify patients with sepsis into subgroups that are more alike from a clinical and/or pathobiological perspective, which could be key for identification of patients who are more likely to benefit from specific immune interventions.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sepse
/
Suscetibilidade a Doenças
/
Interações Hospedeiro-Patógeno
/
Imunidade
Limite:
Humans
Idioma:
En
Revista:
Immunity
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article