Pharmacokinetics and Disposition of Heparin-Binding Growth Factor Midkine Antisense Oligonucleotide Nanoliposomes in Experimental Animal Species and Prediction of Human Pharmacokinetics Using a Physiologically Based Pharmacokinetic Model.

Bai, Haihong; Cheng, Yuanguo; Che, Jinjing

Bai, Haihong; Cheng, Yuanguo; Che, Jinjing.

Afiliação

Bai H; Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Cheng Y; Phase I Clinical Trial Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Che J; Beijing Institute of Microbiology and Epidemiology, Beijing, China.

Front Pharmacol ; 12: 769538, 2021.

Article em En | MEDLINE | ID: mdl-34803711

Palavras-chave

PBPK model; antisense oligonucleotide drug; hepatocellular carcinoma; nanoliposome; pharmacokinetics

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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