Single-cell atlas of splenocytes reveals a critical role of a novel plasma cellâspecific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.

Zhai, Bing; Liu, Xiaoling; Xu, Yaqi; Zhu, Gaizhi; Zhou, Shan; He, Youdi; Wang, Xiaoqian; Su, Wenting; Han, Gencheng; Wang, Renxi

Single-cell atlas of splenocytes reveals a critical role of a novel plasma cellâspecific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.

Zhai, Bing; Liu, Xiaoling; Xu, Yaqi; Zhu, Gaizhi; Zhou, Shan; He, Youdi; Wang, Xiaoqian; Su, Wenting; Han, Gencheng; Wang, Renxi.

Afiliação

Zhai B; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China; Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Liu X; Department of Dermatology, First Medical Centre of Chinese PLA General Hospital, Beijing 100853, China.
Xu Y; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
Zhu G; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
Zhou S; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
He Y; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Wang X; Staidson (Beijing) Biopharmaceuticals Co., Ltd, Beijing 100176, China.
Su W; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China. Electronic address: wtsu@ccmu.edu.cn.
Han G; Beijing Institute of Basic Medical Sciences, Beijing 100850, China. Electronic address: genchenghan@163.com.
Wang R; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China. Electronic address: renxi_wang@ccmu.edu.cn.

Mol Immunol ; 141: 79-86, 2022 01.

Article em En | MEDLINE | ID: mdl-34837777

Assuntos

Anticorpos/imunologia; Centro Germinativo/imunologia; Proteínas de Choque Térmico HSP70/imunologia; Recombinação Genética/imunologia; Hipermutação Somática de Imunoglobulina/imunologia; Animais; Antígenos CD19/imunologia; Biomarcadores/sangue; Diferenciação Celular/imunologia; Rearranjo Gênico/imunologia; Camundongos; Camundongos Knockout; Ovinos; Células Th2/imunologia; Transcrição Gênica/imunologia

Palavras-chave

B cells; Hspa13; Single-cell atlas; Stch; T cells

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Recombinação Genética / Proteínas de Choque Térmico HSP70 / Centro Germinativo / Hipermutação Somática de Imunoglobulina / Anticorpos Limite: Animals Idioma: En Revista: Mol Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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