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The role of beam density and arrangement in non-coplanar IMRT exemplified by the irradiation of brain tumors - Parallels to computed tomographic imaging.
Razinskas, Gary; Stumm, Tobias; Kosmala, Rebekka; Polat, Bülent; Löhr, Mario; Flentje, Michael; Bratengeier, Klaus.
Afiliação
  • Razinskas G; University of Wurzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: Razinskas_G@ukw.de.
  • Stumm T; University of Wurzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: t.stumm@uke.de.
  • Kosmala R; University of Wurzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: Kosmala_R@ukw.de.
  • Polat B; University of Wurzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: Polat_B@ukw.de.
  • Löhr M; University of Wurzburg, Department of Neurosurgery, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: Loehr_M1@ukw.de.
  • Flentje M; University of Wurzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: Flentje_M@ukw.de.
  • Bratengeier K; University of Wurzburg, Department of Radiation Oncology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. Electronic address: Bratengeier_K@ukw.de.
Phys Med ; 96: 204-212, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34863609
PURPOSE: Parallels between the fields of non-coplanar IMRT and non-coplanar computed tomographic reconstruction are highlighted exemplified by the identification of qualified beam configurations for the irradiation of brain tumors. METHODS AND MATERIALS: Four types of beam configurations, i.e. a pure coplanar, a quasi-isotropic and two transitional arrangements, served to systematically examine the impact of parameters such as the sampling rate and the degree of accessibility on plan quality. The resulting set of treatment techniques was compared by means of a Pinnacle3 based retrospective planning study on 18 brain tumor cases. RESULTS AND DISCUSSION: A consistent ranking of IMRT beam constellations according to plan quality was established, which directly reflects the necessities of high-quality CT imaging. Once a sufficient dense beam sampling is secured (given by compliance to Nyquist's theorem), the quasi-isotropic (QIso) irradiation produced best treatment plans, followed by a coplanar irradiation complemented by a single orthogonal non-coplanar beam (CoPl+1). Beams evenly distributed in two orthogonal planes (2-Pl), although using larger portions of the 4π space, proved to be less favorable as the beam sequence becomes less dense. The most unfavorable technique is the pure coplanar technique (CoPl). Generally, techniques with large interbeam distance, i.e. the 2-Pl technique and, to a lesser extent, QIso, are particularly sensitive to a beam number reduction. CONCLUSIONS: Rules established for high quality non-coplanar tomographic imaging are also relevant for non-coplanar IMRT. In this regard, the degree of coverage of 4π space is less important than a sufficient dense sampling.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Radioterapia de Intensidade Modulada Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: Phys Med Assunto da revista: BIOFISICA / BIOLOGIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Radioterapia de Intensidade Modulada Tipo de estudo: Observational_studies Limite: Humans Idioma: En Revista: Phys Med Assunto da revista: BIOFISICA / BIOLOGIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article