Role of rare immune cells in common variable immunodeficiency.
Pediatr Allergy Immunol
; 33(2): e13725, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34937129
ABSTRACT
Common variable immunodeficiency disorder (CVID) is a heterogeneous disorder and the most common symptomatic antibody deficiency disease characterized with hypogammaglobulinemia and a broad range of clinical manifestations. Multiple genetic, epigenetic, and immunological defects are involved in the pathogenesis of CVID. These immunological defects include abnormalities in the number and/or function of B lymphocytes, T lymphocytes, and other rare immune cells. Although some immune cells have a relatively lower proportion among total immune subsets in the human body, they could have important roles in the pathogenesis of immunological disorders like CVID. To the best of our knowledge, this is the first review that described the role of rare immune cells in the pathogenesis and clinical presentations of CVID.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Imunodeficiência de Variável Comum
/
Agamaglobulinemia
Limite:
Humans
Idioma:
En
Revista:
Pediatr Allergy Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
PEDIATRIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Irã