Persister cancer cells: Iron addiction and vulnerability to ferroptosis.
Mol Cell
; 82(4): 728-740, 2022 02 17.
Article
em En
| MEDLINE
| ID: mdl-34965379
ABSTRACT
Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-mediated production of lethal oxygen radicals. This cell death modality has been detected across many organisms, including in mammals, where it can be used as a defense mechanism against pathogens or even harnessed by T cells to sensitize tumor cells toward effective killing. Conversely, ferroptosis is considered one of the main cell death mechanisms promoting degenerative diseases. Emerging evidence suggests that ferroptosis represents a vulnerability in certain cancers. Here, we critically review recent advances linking ferroptosis vulnerabilities of dedifferentiating and persister cancer cells to the dependency of these cells on iron, a potential Achilles heel for small-molecule intervention. We provide a perspective on the mechanisms reliant on iron that contribute to the persister cancer cell state and how this dependency may be exploited for therapeutic benefits.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
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Peroxidação de Lipídeos
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Espécies Reativas de Oxigênio
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Ferroptose
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Ferro
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mol Cell
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2022
Tipo de documento:
Article