Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory.

Veinalde, Ruta; Pidelaserra-Martí, Gemma; Moulin, Coline; Jeworowski, Lara M; Küther, Linda; Buchholz, Christian J; Jäger, Dirk; Ungerechts, Guy; Engeland, Christine E

Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory.

Veinalde, Ruta; Pidelaserra-Martí, Gemma; Moulin, Coline; Jeworowski, Lara M; Küther, Linda; Buchholz, Christian J; Jäger, Dirk; Ungerechts, Guy; Engeland, Christine E.

Afiliação

Veinalde R; Clinical Cooperation Unit Virotherapy, German Cancer Research Center, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
Pidelaserra-Martí G; Clinical Cooperation Unit Virotherapy, German Cancer Research Center, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
Moulin C; Faculty of Health, School of Medicine, Center for Biomedical Research and Education, Institute of Virology and Microbiology, Witten/Herdecke University, Stockumer Str. 10, 58453 Witten, Germany.
Jeworowski LM; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.
Küther L; Faculty of Health, School of Medicine, Center for Biomedical Research and Education, Institute of Virology and Microbiology, Witten/Herdecke University, Stockumer Str. 10, 58453 Witten, Germany.
Buchholz CJ; Ecole Normale Supérieure de Lyon, 15 parvis René Descartes, 69342 Lyon, France.
Jäger D; Clinical Cooperation Unit Virotherapy, German Cancer Research Center, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
Ungerechts G; Faculty of Health, School of Medicine, Center for Biomedical Research and Education, Institute of Virology and Microbiology, Witten/Herdecke University, Stockumer Str. 10, 58453 Witten, Germany.
Engeland CE; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany.

Mol Ther Oncolytics ; 24: 43-58, 2022 Mar 17.

Article em En | MEDLINE | ID: mdl-34977341

Palavras-chave

PD-1; PD-L1; cancer immunotherapy; immune checkpoint; measles virus; oncolytic virus

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Mol Ther Oncolytics Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha