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What is the impact of microvascular complications of diabetes on severe COVID-19?
Basra, Ruman; Whyte, Martin; Karalliedde, Janaka; Vas, Prashanth.
Afiliação
  • Basra R; School of Cardiovascular Medicine & Sciences, King's College London, London, UK.
  • Whyte M; Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK; Department of Diabetes, King's College NHS Foundation Trust, London, UK; King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK.
  • Karalliedde J; School of Cardiovascular Medicine & Sciences, King's College London, London, UK; King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK.
  • Vas P; Department of Diabetes, King's College NHS Foundation Trust, London, UK; King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK. Electronic address: prashanth.vas@nhs.net.
Microvasc Res ; 140: 104310, 2022 03.
Article em En | MEDLINE | ID: mdl-34979154
ABSTRACT
Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Endotélio Vascular / Trombofilia / Angiopatias Diabéticas / Pandemias / SARS-CoV-2 / COVID-19 / Microcirculação Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Microvasc Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Endotélio Vascular / Trombofilia / Angiopatias Diabéticas / Pandemias / SARS-CoV-2 / COVID-19 / Microcirculação Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Microvasc Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido