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Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity: Synthesis, in vitro assays and in silico study.
Ali, Eslam M H; Mersal, Karim I; Ammar, Usama M; Zaraei, Seyed-Omar; Abdel-Maksoud, Mohammed S; El-Gamal, Mohammed I; Haque, Md Mamunul; Das, Tanuza; Kim, Eunice EunKyeong; Lee, Jun-Seok; Lee, Kwan Hyi; Kim, Hee-Kwon; Oh, Chang-Hyun.
Afiliação
  • Ali EMH; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea; University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University fo
  • Mersal KI; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea; University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University fo
  • Ammar UM; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0NR, Scotland, United Kingdom.
  • Zaraei SO; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea; University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea.
  • Abdel-Maksoud MS; Medicinal & Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre NRC (ID: 60014618)), Dokki, Giza, 12622, Egypt.
  • El-Gamal MI; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Manso
  • Haque MM; Department of Pharmacology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Das T; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
  • Kim EE; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
  • Lee JS; Department of Pharmacology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Lee KH; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
  • Kim HK; Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Republic of Korea; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research
  • Oh CH; Center of Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea; University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea. Electronic address: choh@kist.re.kr.
Eur J Pharm Sci ; 171: 106115, 2022 Apr 01.
Article em En | MEDLINE | ID: mdl-34995782
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Antineoplásicos Limite: Animals Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Antineoplásicos Limite: Animals Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article