Epigenetic regulation of 5&#945; reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.

Bar-Sadeh, Ben; Amichai, Or E; Pnueli, Lilach; Begum, Khurshida; Leeman, Gregory; Emes, Richard D; Stöger, Reinhard; Bentley, Gillian R; Melamed, Philippa

Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.

Bar-Sadeh, Ben; Amichai, Or E; Pnueli, Lilach; Begum, Khurshida; Leeman, Gregory; Emes, Richard D; Stöger, Reinhard; Bentley, Gillian R; Melamed, Philippa.

Afiliação

Bar-Sadeh B; Faculty of Biology, Technion-Israel Institute of Technology, 32000, Haifa, Israel.
Amichai OE; Faculty of Biology, Technion-Israel Institute of Technology, 32000, Haifa, Israel.
Pnueli L; Faculty of Biology, Technion-Israel Institute of Technology, 32000, Haifa, Israel.
Begum K; Department of Anthropology, Durham University, Durham, DH1 3LE, UK.
Leeman G; School of Biosciences, University of Nottingham, Nottingham, LE12 5RD, UK.
Emes RD; School of Veterinary Medicine and Sciences, University of Nottingham, Nottingham, LE12 5RD, UK.
Stöger R; School of Biosciences, University of Nottingham, Nottingham, LE12 5RD, UK.
Bentley GR; Department of Anthropology, Durham University, Durham, DH1 3LE, UK.
Melamed P; Faculty of Biology, Technion-Israel Institute of Technology, 32000, Haifa, Israel. philippa@tx.technion.ac.il.

BMC Biol ; 20(1): 11, 2022 01 07.

Article em En | MEDLINE | ID: mdl-34996447

Assuntos

3-Oxo-5-alfa-Esteroide 4-Desidrogenase/metabolismo; Colestenona 5 alfa-Redutase; Kisspeptinas; Proteínas de Membrana/metabolismo; Adaptação Fisiológica; Animais; Colestenona 5 alfa-Redutase/genética; Colestenona 5 alfa-Redutase/metabolismo; Epigênese Genética; Feminino; Hormônio Liberador de Gonadotropina/genética; Hormônio Liberador de Gonadotropina/metabolismo; Humanos; Kisspeptinas/genética; Kisspeptinas/metabolismo; Camundongos

Palavras-chave

5α reductase-1; Aging; Colitis; Hypothalamus; Menopause; Mice; Ovary; Puberty; Reproduction; Women

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: 3-Oxo-5-alfa-Esteroide 4-Desidrogenase / Colestenona 5 alfa-Redutase / Kisspeptinas / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: BMC Biol Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Israel

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