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Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903.
Baradaran-Heravi, Alireza; Bauer, Claudia C; Pickles, Isabelle B; Hosseini-Farahabadi, Sara; Balgi, Aruna D; Choi, Kunho; Linley, Deborah M; Beech, David J; Roberge, Michel; Bon, Robin S.
Afiliação
  • Baradaran-Heravi A; Department of Biochemistry and Molecular Biology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: abara@mail.ubc.ca.
  • Bauer CC; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.
  • Pickles IB; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK; School of Chemistry, University of Leeds, Leeds, UK.
  • Hosseini-Farahabadi S; Department of Biochemistry and Molecular Biology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Balgi AD; Department of Biochemistry and Molecular Biology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Choi K; Department of Biochemistry and Molecular Biology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Linley DM; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.
  • Beech DJ; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.
  • Roberge M; Department of Biochemistry and Molecular Biology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Bon RS; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. Electronic address: r.bon@leeds.ac.uk.
J Biol Chem ; 298(2): 101546, 2022 02.
Article em En | MEDLINE | ID: mdl-34999117
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Códon sem Sentido / Canais de Cátion TRPC / Aminoglicosídeos / Indazóis Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Códon sem Sentido / Canais de Cátion TRPC / Aminoglicosídeos / Indazóis Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article