[The value of re-sampling for patients who had failed non-invasive prenatal testing due to low cell-free fetal DNA fraction].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 39(2): 135-138, 2022 Feb 10.
Article
em Zh
| MEDLINE
| ID: mdl-35076906
ABSTRACT
OBJECTIVE:
To assess the value of re-sampling for patients who had failed non-invasive prenatal testing (NIPT) due to low cell-free fetal DNA (cffDNA) fraction.METHODS:
Clinical data of 20 387 patients undergoing NIPT test was reviewed. The patients were re-sampled when initial blood test did not yield a result due to cffDNA fraction. The results were analyzed, and the outcome of pregnancy was followed up.RESULTS:
Among all samples, 17 (0.08%) had failed to yield a result due to low cffDNA fraction, all of which accepted re-sampling. A result was attained in 16 cases, with a success rate of 94.12%. Only one sample had failed the re-test.CONCLUSION:
For patients who had failed the initial NIPT due to low cffDNA fraction, re-sampling should be considered with gestational week and ultrasound results taken into consideration.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ácidos Nucleicos Livres
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China