Roadmap on plasticity and epigenetics in cancer.
Phys Biol
; 19(3)2022 04 18.
Article
em En
| MEDLINE
| ID: mdl-35078159
ABSTRACT
The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Epigênese Genética
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Phys Biol
Assunto da revista:
BIOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos