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Roadmap on plasticity and epigenetics in cancer.
Foo, Jasmine; Basanta, David; Rockne, Russell C; Strelez, Carly; Shah, Curran; Ghaffarian, Kimya; Mumenthaler, Shannon M; Mitchell, Kelly; Lathia, Justin D; Frankhouser, David; Branciamore, Sergio; Kuo, Ya-Huei; Marcucci, Guido; Velde, Robert Vander; Marusyk, Andriy; Huang, Sui; Hari, Kishore; Jolly, Mohit Kumar; Hatzikirou, Haralampos; Poels, Kamrine E; Spilker, Mary E; Shtylla, Blerta; Robertson-Tessi, Mark; Anderson, Alexander R A.
Afiliação
  • Foo J; School of Mathematics, University of Minnesota, Twin Cities, MN 55455, United States of America.
  • Basanta D; Integrated Mathematical Oncology Department, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States of America.
  • Rockne RC; Department of Computational and Quantitative Medicine, Division of Mathematical Oncology, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA 91010, United States of America.
  • Strelez C; Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA 90064, United States of America.
  • Shah C; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.
  • Ghaffarian K; Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA 90064, United States of America.
  • Mumenthaler SM; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, United States of America.
  • Mitchell K; Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA 90064, United States of America.
  • Lathia JD; Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA 90064, United States of America.
  • Frankhouser D; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.
  • Branciamore S; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, United States of America.
  • Kuo YH; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America.
  • Marcucci G; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America.
  • Velde RV; Case Comprehensive Cancer Center, Cleveland, OH 44106, United States of America.
  • Marusyk A; Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH 44195, United States of America.
  • Huang S; Department of Population Sciences, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA 91010, United States of America.
  • Hari K; Department of Computational and Quantitative Medicine, Division of Mathematical Oncology, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA 91010, United States of America.
  • Jolly MK; Department of Hematologic Malignancies Translational Science, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA 91010, United States of America.
  • Hatzikirou H; Department of Hematologic Malignancies Translational Science, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA 91010, United States of America.
  • Poels KE; Department of Cancer Physiology, Moffitt Cancer Center, Tampa, FL 33612, United States of America.
  • Spilker ME; Department of Molecular Biology, University of South Florida Health, Tampa, FL 33612, United States of America.
  • Shtylla B; Department of Cancer Physiology, Moffitt Cancer Center, Tampa, FL 33612, United States of America.
  • Robertson-Tessi M; Institute for Systems Biology, Seattle, WA 98109, United States of America.
  • Anderson ARA; Centre for BioSystems Science and Engineering, Indian Institute of Science, 560012 Bangalore, India.
Phys Biol ; 19(3)2022 04 18.
Article em En | MEDLINE | ID: mdl-35078159
ABSTRACT
The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Epigênese Genética / Neoplasias Limite: Humans Idioma: En Revista: Phys Biol Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Epigênese Genética / Neoplasias Limite: Humans Idioma: En Revista: Phys Biol Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos