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Structure-Activity Relationship of 3-Methylcytidine-5'-α,ß-methylenediphosphates as CD73 Inhibitors.
Scortichini, Mirko; Idris, Riham Mohammed; Moschütz, Susanne; Keim, Antje; Salmaso, Veronica; Dobelmann, Clemens; Oliva, Paola; Losenkova, Karolina; Irjala, Heikki; Vaittinen, Samuli; Sandholm, Jouko; Yegutkin, Gennady G; Sträter, Norbert; Junker, Anna; Müller, Christa E; Jacobson, Kenneth A.
Afiliação
  • Scortichini M; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Idris RM; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
  • Moschütz S; Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.
  • Keim A; Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.
  • Salmaso V; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Dobelmann C; European Institute for Molecular Imaging (EIMI), University of Münster, Waldeyerstrasse 15, D-48149 Münster, Germany.
  • Oliva P; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Losenkova K; Medicity Research Laboratory, University of Turku, 20520 Turku, Finland.
  • Irjala H; Department of Otorhinolaryngology-Head and Neck Surgery, Turku University Hospital and Turku University, 20520 Turku, Finland.
  • Vaittinen S; Department of Pathology, Turku University Hospital and Turku University, 20520 Turku, Finland.
  • Sandholm J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
  • Yegutkin GG; Medicity Research Laboratory, University of Turku, 20520 Turku, Finland.
  • Sträter N; Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.
  • Junker A; European Institute for Molecular Imaging (EIMI), University of Münster, Waldeyerstrasse 15, D-48149 Münster, Germany.
  • Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
  • Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
J Med Chem ; 65(3): 2409-2433, 2022 02 10.
Article em En | MEDLINE | ID: mdl-35080883
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Nucleotídeos de Citosina / Difosfonatos / Inibidores Enzimáticos Limite: Adult / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Nucleotídeos de Citosina / Difosfonatos / Inibidores Enzimáticos Limite: Adult / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos