Temperature Effect on Nerve Conduction Block Induced by High-Frequency (kHz) Biphasic Stimulation.
Neuromodulation
; 26(3): 607-613, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-35088749
ABSTRACT
OBJECTIVES:
This study aims to determine temperature effect on nerve conduction block induced by high-frequency (kHz) biphasic stimulation (HFBS). MATERIALS ANDMETHODS:
Frog sciatic nerve-muscle preparation was immersed in Ringer's solution at a temperature of 15 or 20 °C. To induce muscle contractions, a bipolar cuff electrode delivered low-frequency (0.25 Hz) stimulation to the nerve. To induce nerve block, a tripolar cuff electrode was placed distal to the bipolar cuff electrode to deliver HFBS (2 or 10 kHz). A bipolar hook electrode distal to the blocking electrode was used to confirm that the nerve block occurred locally at the site of HFBS. A thread tied onto the foot was attached to a force transducer to measure the muscle contraction force.RESULTS:
At 15 °C, both 2- and 10-kHz HFBSs elicited an initial transient muscle contraction and then produced nerve block during the stimulation (ie, acute block), with the 10 kHz having a significantly (p < 0.001) higher acute block threshold (5.9 ± 0.8 mA peak amplitude) than the 2 kHz (1.9 ± 0.3 mA). When the temperature was increased to 20 °C, the acute block threshold for the 10-kHz HFBS was significantly (p < 0.0001) decreased from 5.2 ± 0.3 to 4.4 ± 0.2 mA, whereas the 2-kHz HFBS induced a tonic muscle contraction during the stimulation but elicited nerve block after terminating the 2-kHz HFBS (ie, poststimulation block) with an increased block duration at a higher stimulation intensity.CONCLUSION:
Temperature has an important influence on HFBS-induced nerve block. The blocking mechanisms underlying acute and poststimulation nerve blocks are likely to be very different.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bloqueio Nervoso
/
Condução Nervosa
Limite:
Humans
Idioma:
En
Revista:
Neuromodulation
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China