Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway.

Begum, Habeebunnisa; Chirra, Nagaraju; Kumar, Dinesh; Murugesan, Periyasamy; Kantevari, Srinivas; Tangutur, Anjana Devi

Begum, Habeebunnisa; Chirra, Nagaraju; Kumar, Dinesh; Murugesan, Periyasamy; Kantevari, Srinivas; Tangutur, Anjana Devi.

Afiliação

Begum H; Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Chirra N; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Kumar D; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Murugesan P; Fluoro & Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Kantevari S; Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Tangutur AD; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.

Drug Dev Res ; 83(4): 910-926, 2022 06.

Article em En | MEDLINE | ID: mdl-35092073

Assuntos

Neoplasias Pancreáticas; Quinolinas; Aminas; Apoptose; Autofagia; Linhagem Celular Tumoral; Transição Epitelial-Mesenquimal; Humanos; Neoplasias Pancreáticas/tratamento farmacológico; Proteínas Proto-Oncogênicas c-akt/metabolismo; Quinolinas/farmacologia; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Neoplasias Pancreáticas

Palavras-chave

apoptosis; autophagy; pancreatic cancer; quinoline derivative

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Quinolinas Limite: Humans Idioma: En Revista: Drug Dev Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

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