Sex Differences in Dilated Cardiomyopathy Prognosis.
Int Heart J
; 63(1): 36-42, 2022.
Article
em En
| MEDLINE
| ID: mdl-35095074
ABSTRACT
Dilated cardiomyopathy (DCM) is the most common type of cardiomyopathy, and it often has a poor outcome. Sex differences in the prognosis of patients with DCM remain controversial. The present meta-analysis aimed to investigate whether sex plays a role in the outcome of patients with DCM and to provide real-world information on these potential sex differences for physicians and patients.We searched the PubMed, Cochrane, and EMBASE databases for published cohort studies up to February 16, 2020 that reported sex-specific prognostic outcomes (e.g., all-cause mortality; sudden cardiac death (SCD) ) in patients with DCM.Finally, 5 clinical cohort studies with a total of 5,709 patients were included. The results showed that males with DCM had a higher risk of all-cause mortality than females (HR 1.61, 95% CI 1.36~1.90; P < 0.00001). Next, the included studies were divided into short-term (< 5 years) and long-term (≥ 5 years) outcome groups by follow-up duration. Males showed a higher risk of all-cause mortality in both subgroups (< 5 years, HR 1.59, 95% CI 1.13~2.23; P = 0.008; ≥ 5 years, HR 1.65, 95% CI 1.33~2.05; P < 0.00001). In addition, the risks of SCD (HR 1.80, 95% CI 1.63~2.61; P = 0.002) and cardiovascular mortality in males (HR 1.67, 95% CI 1.25~2.23; P = 0.0005) were higher than those in females.The evidence from the published studies suggested that compared with females, males with DCM had an increased risk of all-cause mortality, cardiovascular mortality, and SCD.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Cardiomiopatia Dilatada
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Morte Súbita Cardíaca
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Int Heart J
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article