Your browser doesn't support javascript.
loading
Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE).
Lai, Heidi T M; Imamura, Fumiaki; Korat, Andres V Ardisson; Murphy, Rachel A; Tintle, Nathan; Bassett, Julie K; Chen, Jiaying; Kröger, Janine; Chien, Kuo-Liong; Senn, Mackenzie; Wood, Alexis C; Forouhi, Nita G; Schulze, Matthias B; Harris, William S; Vasan, Ramachandran S; Hu, Frank; Giles, Graham G; Hodge, Allison; Djousse, Luc; Brouwer, Ingeborg A; Qian, Frank; Sun, Qi; Wu, Jason H Y; Marklund, Matti; Lemaitre, Rozenn N; Siscovick, David S; Fretts, Amanda M; Shadyab, Aladdin H; Manson, JoAnn E; Howard, Barbara V; Robinson, Jennifer G; Wallace, Robert B; Wareham, Nick J; Chen, Yii-Der Ida; Rotter, Jerome I; Tsai, Michael Y; Micha, Renata; Mozaffarian, Dariush.
Afiliação
  • Lai HTM; Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
  • Imamura F; Department of Primary Care and Public Health, Imperial College London, London, U.K.
  • Korat AVA; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
  • Murphy RA; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Tintle N; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  • Bassett JK; School of Population & Public Health, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Chen J; Department of Mathematics and Statistics, Dordt University, Sioux Center, IA.
  • Kröger J; Fatty Acid Research Institute, Sioux Falls, SD.
  • Chien KL; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  • Senn M; Division of Aging, Brigham and Women's Hospital, Boston, MA.
  • Wood AC; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Forouhi NG; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Republic of China.
  • Schulze MB; U.S. Department of Agriculture/Agriculture Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Harris WS; U.S. Department of Agriculture/Agriculture Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Vasan RS; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.
  • Hu F; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Giles GG; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Hodge A; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
  • Djousse L; Fatty Acid Research Institute, Sioux Falls, SD.
  • Brouwer IA; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD.
  • Qian F; Boston University School of Medicine, Boston, MA.
  • Sun Q; The Framingham Heart Study, Framingham, MA.
  • Wu JHY; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Marklund M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  • Lemaitre RN; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  • Siscovick DS; Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
  • Fretts AM; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
  • Shadyab AH; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  • Manson JE; Divisions of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  • Howard BV; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
  • Robinson JG; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Wallace RB; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Wareham NJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  • Chen YI; The George Institute for Global Health, the Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Rotter JI; Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
  • Tsai MY; The George Institute for Global Health, the Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Micha R; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
  • Mozaffarian D; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
Diabetes Care ; 45(4): 854-863, 2022 04 01.
Article em En | MEDLINE | ID: mdl-35142845
ABSTRACT

OBJECTIVE:

Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis. RESEARCH DESIGN AND

METHODS:

We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.

RESULTS:

During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-182, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-182, 0.89 (0.73-1.07); and trans/cis-182, 0.87 (0.73-1.03). Trans-161n-9, total trans-181, and total trans-182 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1).

CONCLUSIONS:

Circulating individual trans-182 TFA biomarkers were not associated with risk of T2D, while trans-161n-9, total trans-181, and total trans-182 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ácidos Graxos trans / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Humans Idioma: En Revista: Diabetes Care Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Marrocos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ácidos Graxos trans / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Humans Idioma: En Revista: Diabetes Care Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Marrocos