[Research advances on the role of competing endogenous RNAs in wound healing].
Zhonghua Shao Shang Za Zhi
; 38(1): 84-89, 2022 Jan 20.
Article
em Zh
| MEDLINE
| ID: mdl-35152689
ABSTRACT
Wound healing, as one of the important public health issues, has been a worldwide problem. Due to the unique biological wound environment, wound healing is a very complex process with current treatments requiring long cycles, being poorly effective, and bringing high economic burden to patients. An increasing number of studies have shown that non-coding RNAs (ncRNAs) play important roles in wound healing process. The competing endogenous RNAs (ceRNAs) hypothesis in recent years is a new proposal on the inter-regulation of RNAs, which suggests a "mode of communication" between different RNAs. ceRNA regulatory network (ceRNET) combines the functions of protein-coding mRNA with ncRNA (e.g., microRNA, long non-coding RNA, pseudogenes, and circular RNA). Recent studies have shown that ceRNAs play important roles in wound healing, which may provide new effective therapeutic targets for wound healing. This paper starting with ceRNET systematically reviewed the research progress on the effects of various ceRNAs in wound healing and the future research challenges, with the aim to deeply explore the molecular mechanisms and clinical significance of ceRNAs in the process of wound healing.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
RNA Longo não Codificante
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Shao Shang Za Zhi
Assunto da revista:
TRAUMATOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China