Recent advances in construction and regulation of yeast cell factories.
World J Microbiol Biotechnol
; 38(4): 57, 2022 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-35174424
ABSTRACT
The past decade has witnessed the rapid progress in development of synthetic biology, and advances in construction of yeast cell factories open vast opportunities for green and sustainable production of chemicals. Focusing on the progress in yeast engineering for production of plant natural products in the last 5 years, this review introduces different yeast chassis used for cell factory construction, including Saccharomyces cerevisiae, Yarrowia lipolytica and Komagataella phaffii, together with the emerging genome editing tools. The metabolic regulation strategies developed for yeast engineering are highlighted, such as subcellular pathway localization dynamic regulation, and transporter engineering. C1-based chemical bioproduction by engineered yeast is also covered. Finally, the existing challenges and future prospects in creating efficient yeast cell factories are summarized.
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MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Yarrowia
Idioma:
En
Revista:
World J Microbiol Biotechnol
Ano de publicação:
2022
Tipo de documento:
Article