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Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program.
Onuki, Mamiko; Yamamoto, Kasumi; Yahata, Hideaki; Kanao, Hiroyuki; Horie, Koji; Konnai, Katsuyuki; Nio, Ai; Takehara, Kazuhiro; Kamiura, Shoji; Tsuda, Naotake; Takei, Yuji; Shigeta, Shogo; Nakai, Hidekatsu; Yoshida, Hiroyuki; Motohara, Takeshi; Kato, Tatsuya; Nakamura, Keiichiro; Hamanishi, Junzo; Tasaka, Nobutaka; Ishikawa, Mitsuya; Kado, Nobuhiro; Taira, Yusuke; Mori, Mayuyo; Iwata, Takashi; Takahashi, Fumiaki; Kukimoto, Iwao; Yoshikawa, Hiroyuki; Yaegashi, Nobuo; Matsumoto, Koji.
Afiliação
  • Onuki M; Department of Obstetrics and Gynecology, School of Medicine, Showa University, Tokyo 142-8666, Japan.
  • Yamamoto K; Department of Gynecologic Oncology, Hyogo Cancer Center, Akashi 673-0021, Japan.
  • Yahata H; Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Kanao H; Department of Gynecology, Cancer Institute Hospital, Tokyo 135-0063, Japan.
  • Horie K; Department of Gynecology, Saitama Cancer Center, Saitama 362-0806, Japan.
  • Konnai K; Department of Gynecology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Nio A; Gynecology Service, NHO Kyushu Cancer Center, Fukuoka 811-1395, Japan.
  • Takehara K; Department of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama 791-0280, Japan.
  • Kamiura S; Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
  • Tsuda N; Department of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume 830-0011, Japan.
  • Takei Y; Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke 329-0498, Japan.
  • Shigeta S; Department of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
  • Nakai H; Department of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.
  • Yoshida H; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan.
  • Motohara T; Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
  • Kato T; Department of Obstetrics and Gynecology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
  • Nakamura K; Department of Obstetrics and Gynecology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama 700-8558, Japan.
  • Hamanishi J; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
  • Tasaka N; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
  • Ishikawa M; Department of Gynecology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
  • Kado N; Division of Gynecology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Taira Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan.
  • Mori M; Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
  • Iwata T; Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
  • Takahashi F; Division of Medical Engineering, Department of Information Science, Iwate Medical University, Yahaba 028-3694, Japan.
  • Kukimoto I; Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
  • Yoshikawa H; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
  • Yaegashi N; Department of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
  • Matsumoto K; Department of Obstetrics and Gynecology, School of Medicine, Showa University, Tokyo 142-8666, Japan.
Vaccines (Basel) ; 10(2)2022 Jan 25.
Article em En | MEDLINE | ID: mdl-35214646
ABSTRACT
Since the human papillomavirus (HPV) vaccination program for Japanese girls aged 12-16 years began in 2010, vaccination uptake has been low in women born before 1993 but high (approximately 70%) in those born during 1994-1999. We previously compared the prevalence of vaccine types HPV16 and HPV18 in cervical intraepithelial neoplasia grade 1-3 (CIN1-3) or adenocarcinoma in situ (AIS) between vaccinated and unvaccinated cohorts and found direct protection effects among vaccinated women in Japan. In this study, we focused on changes in HPV16/18 prevalence among "unvaccinated" cohorts with CIN/AIS. We analyzed HPV16/18 prevalence among 5051 unvaccinated women aged <40 years, newly diagnosed with CIN/AIS during 2012-2021 for time trends. Declining trends in HPV16/18 prevalence over 9 years were observed in CIN1 (36.0-10.0%, Ptrend = 0.03) and CIN2-3/AIS (62.5-36.4%, Ptrend = 0.07) among women aged <25 years. HPV16/18 prevalence in CIN1 and CIN2-3/AIS diagnosed at age 20-24 years was lower in 1994-1999 birth cohorts compared with 1988-1993 birth cohorts (4.5% vs. 25.7% for CIN1 and 40.0% vs. 58.1% for CIN2-3/AIS, both p = 0.04). Significant reduction in HPV16/18 prevalence among young unvaccinated women with CIN1 and CIN2-3/AIS suggests herd effects of HPV vaccination in Japan.
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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies Idioma: En Revista: Vaccines (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies Idioma: En Revista: Vaccines (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão