Assessing the impact of air pollutants on clinical visits for childhood allergic respiratory disease induced by house dust mite in Shanghai, China.
Respir Res
; 23(1): 48, 2022 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-35248029
ABSTRACT
BACKGROUND:
The prevalence of allergic respiratory disease (ARD) is increasing worldwide during the last few decades, causing a great disease burden especially for children. Air pollution has been increasingly considered as a potential contributor to this trend, but its role in ARD induced by house dust mite (HDM-ARD) remains unclear, especially in time-series study.METHODS:
A positive reporting of respiratory allergy to named allergens was included by serum specific IgE testing. A time series Quasi-Poisson regression with distributed lag non-linear model, combined with generalized linear model was used to examine the effects of air pollutants on ARD, HDM-ARD and ARD induced by non-house dust mite (NHDM-ARD).RESULTS:
A total of 16,249 cases of ARD, including 8,719 HDM-ARD and 8,070 NHDM-ARD from 1 Jan 2013 to 31 Dec 2017 were involved in this study. Air pollutants were significantly associated with clinical visits for childhood ARD and HDM-ARD. Exposure to higher O3 and interquartile range (IQR) increment in O3 (40.6 µg/m3) increased the risks of clinical visits for childhood HDM-ARD (RRlag0-5 for the 95th percentile of O3 1.26, 95% confidence interval (CI) 1.03, 1.55; RRlag0-5 for IQR increment (40.6 µg/m3) 1.09, 95% CI 1.01, 1.17) and ARD (RRlag0-5 for the 95th percentile of O3 1.19, 95% CI 1.03, 1.38; RRlag0-5 for IQR increment (40.6 µg/m3) 1.06, 95% CI 1.01, 1.12). In addition, higher O3 was associated with increased RR of boys with ARD (RRlag0-5 for the 95th percentile 1.26, 95% CI 1.05, 1.51; RRlag0-5 for IQR increment (40.6 µg/m3) 1.09, 95% CI 1.02, 1.16) and HDM-ARD (RRlag0-5 for the 95th percentile 1.36, 95% CI 1.06, 1.75; RRlag0-5 for IQR increment (40.6 µg/m3) 1.11, 95% CI 1.02, 1.22), but not in girls.CONCLUSIONS:
Exposure to O3 appeared to be a trigger of clinical visits for childhood ARD, especially for HDM-ARD and boys. These findings provide novel evidence on the impact of air pollution on HDM-ARD, which may have significant implications for designing effective intervention programs to control and prevent childhood ARD, especially HDM-ARD, in China and other similar developing countries.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Visita a Consultório Médico
/
Transtornos Respiratórios
/
Pyroglyphidae
/
Poluentes Atmosféricos
/
Poeira
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Respir Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China