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Juvenile hormone-induced histone deacetylase 3 suppresses apoptosis to maintain larval midgut in the yellow fever mosquito.
Gaddelapati, Sharath Chandra; Albishi, Najla M; Dhandapani, Ramesh Kumar; Palli, Subba Reddy.
Afiliação
  • Gaddelapati SC; Department of Entomology, University of Kentucky, Lexington, KY 40546.
  • Albishi NM; Department of Entomology, University of Kentucky, Lexington, KY 40546.
  • Dhandapani RK; Department of Entomology, University of Kentucky, Lexington, KY 40546.
  • Palli SR; Department of Entomology, University of Kentucky, Lexington, KY 40546.
Proc Natl Acad Sci U S A ; 119(11): e2118871119, 2022 03 15.
Article em En | MEDLINE | ID: mdl-35259020
SignificanceJuvenile hormone (JH), a sesquiterpenoid, regulates many aspects of insect development, including maintenance of the larval stage by preventing metamorphosis. In contrast, ecdysteroids promote metamorphosis by inducing the E93 transcription factor, which triggers apoptosis of larval cells and remodeling of the larval midgut. We discovered that JH suppresses precocious larval midgut-remodeling by inducing an epigenetic modifier, histone deacetylase 3 (HDAC3). JH-induced HDAC3 deacetylates the histone H4 localized at the promoters of proapoptotic genes, resulting in the suppression of these genes. This eventually prevents programmed cell death of midgut cells and midgut-remodeling during larval stages. These studies identified a previously unknown mechanism of JH action in blocking premature remodeling of the midgut during larval feeding stages.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Apoptose / Aedes / Sistema Digestório / Histona Desacetilases / Hormônios Juvenis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Apoptose / Aedes / Sistema Digestório / Histona Desacetilases / Hormônios Juvenis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article