Decabromodiphenyl ether induces ROS-mediated intestinal toxicity through the Keap1-Nrf2 pathway.

Li, Shiqi; Yuan, Jinwen; Che, Siyan; Zhang, Li; Ruan, Zheng; Sun, Xiaoming

Li, Shiqi; Yuan, Jinwen; Che, Siyan; Zhang, Li; Ruan, Zheng; Sun, Xiaoming.

Afiliação

Li S; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang, China.
Yuan J; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang, China.
Che S; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang, China.
Zhang L; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang, China.
Ruan Z; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang, China.
Sun X; State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang, China.

J Biochem Mol Toxicol ; 36(4): e22995, 2022 Apr.

Article em En | MEDLINE | ID: mdl-35266255

Assuntos

Retardadores de Chama; Éteres Difenil Halogenados; Animais; Células CACO-2; Retardadores de Chama/toxicidade; Éteres Difenil Halogenados/toxicidade; Humanos; Intestinos; Proteína 1 Associada a ECH Semelhante a Kelch/genética; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Camundongos; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; RNA Mensageiro; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Keap1-Nrf2; intestinal toxicity; oxidative stress; polybrominated diphenyl ethers

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Éteres Difenil Halogenados / Retardadores de Chama Limite: Animals / Humans Idioma: En Revista: J Biochem Mol Toxicol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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