[The Basic Research of Antigen-antibody Reaction in Lung Transplantation].
Kyobu Geka
; 75(4): 244-251, 2022 Apr.
Article
em Ja
| MEDLINE
| ID: mdl-35342153
ABSTRACT
Lung transplantation has become popular in Japan, showing better survival rate than other countries. However, the results are still not satisfactory compared with other solid organ transplantation. One of the reasons for this might be that knowledge on donor-specific antibodies or antibody-related rejection, which has been attracting attention these days, is less than that of kidney or liver transplantation. Our laboratory has continued basic research in this field using rodent lung transplantation model. We have previously shown that type V collagen is associated in chronic rejection as an autoimmune, and that oral administration of type V collagen induces tolerance. The murine chronic rejection model of the minor antigen mismatch was developed, and involvement of the humoral immunity and role of the complement activation were shown. We are now studying the effects of immune checkpoint molecules, which play a central role in the field of cancer therapy, on rejection after lung transplantation. We are also working to verify the effects of anti-complement drugs and molecular targeted drugs in the future treatment on rejection.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Transplante de Pulmão
/
Rejeição de Enxerto
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
Ja
Revista:
Kyobu Geka
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão