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A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Ghigo, Alessandra; Murabito, Alessandra; Sala, Valentina; Pisano, Anna Rita; Bertolini, Serena; Gianotti, Ambra; Caci, Emanuela; Montresor, Alessio; Premchandar, Aiswarya; Pirozzi, Flora; Ren, Kai; Della Sala, Angela; Mergiotti, Marco; Richter, Wito; de Poel, Eyleen; Matthey, Michaela; Caldrer, Sara; Cardone, Rosa A; Civiletti, Federica; Costamagna, Andrea; Quinney, Nancy L; Butnarasu, Cosmin; Visentin, Sonja; Ruggiero, Maria Rosaria; Baroni, Simona; Crich, Simonetta Geninatti; Ramel, Damien; Laffargue, Muriel; Tocchetti, Carlo G; Levi, Renzo; Conti, Marco; Lu, Xiao-Yun; Melotti, Paola; Sorio, Claudio; De Rose, Virginia; Facchinetti, Fabrizio; Fanelli, Vito; Wenzel, Daniela; Fleischmann, Bernd K; Mall, Marcus A; Beekman, Jeffrey; Laudanna, Carlo; Gentzsch, Martina; Lukacs, Gergely L; Pedemonte, Nicoletta; Hirsch, Emilio.
Afiliação
  • Ghigo A; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Murabito A; Kither Biotech Srl, 10126, Torino, Italy.
  • Sala V; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Pisano AR; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Bertolini S; Kither Biotech Srl, 10126, Torino, Italy.
  • Gianotti A; Chiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, 43122 Parma, Italy.
  • Caci E; Chiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, 43122 Parma, Italy.
  • Montresor A; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
  • Premchandar A; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
  • Pirozzi F; Division of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
  • Ren K; Cystic Fibrosis Translational Research Laboratory "Daniele Lissandrini," Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
  • Della Sala A; Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada.
  • Mergiotti M; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Richter W; Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy.
  • de Poel E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Matthey M; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Caldrer S; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Cardone RA; Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine Mobile, AL 36688, USA.
  • Civiletti F; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, Netherlands.
  • Costamagna A; Department of Systems Physiology, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.
  • Quinney NL; Division of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
  • Butnarasu C; Cystic Fibrosis Translational Research Laboratory "Daniele Lissandrini," Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
  • Visentin S; Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari , 70126 Bari, Italy.
  • Ruggiero MR; Department of Anesthesia and Critical Care Medicine, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
  • Baroni S; Department of Anesthesia and Critical Care Medicine, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
  • Crich SG; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Ramel D; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Laffargue M; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Tocchetti CG; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Levi R; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Conti M; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Lu XY; Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University , 31432 Toulouse, France.
  • Melotti P; Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University , 31432 Toulouse, France.
  • Sorio C; Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy.
  • De Rose V; Interdepartmental Center of Clinical and Translational Research (CIRCET), Federico II University, 80131 Naples, Italy.
  • Facchinetti F; Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, 80131 Naples, Italy.
  • Fanelli V; Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.
  • Wenzel D; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA.
  • Fleischmann BK; School of life Science and Technology, Xi'an Jiaotong University, 710049 Xi'an Shaanxi, P.R. China.
  • Mall MA; Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy.
  • Beekman J; Division of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
  • Laudanna C; Cystic Fibrosis Translational Research Laboratory "Daniele Lissandrini," Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
  • Gentzsch M; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
  • Lukacs GL; Chiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, 43122 Parma, Italy.
  • Pedemonte N; Department of Anesthesia and Critical Care Medicine, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
  • Hirsch E; Department of Systems Physiology, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.
Sci Transl Med ; 14(638): eabl6328, 2022 03 30.
Article em En | MEDLINE | ID: mdl-35353541
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Regulador de Condutância Transmembrana em Fibrose Cística / Fosfatidilinositol 3-Quinase Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Regulador de Condutância Transmembrana em Fibrose Cística / Fosfatidilinositol 3-Quinase Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália