Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis.
Proc Natl Acad Sci U S A
; 119(15): e2201071119, 2022 04 12.
Article
em En
| MEDLINE
| ID: mdl-35377802
The molecular control of insect metamorphosis from larva to pupa to adult has long been a mystery. The Broad and E93 transcription factors, which can modify chromatin domains, are known to direct the production of the pupa and the adult, respectively. We now show that chinmo, a gene related to broad, is essential for the repression of these metamorphic genes. Chinmo is strongly expressed during the formation and growth of the larva and its removal results in the precocious expression of broad and E93 in the first stage larva, causing a shift from larval to premetamorphic functions. This trinity of Chinmo, Broad, and E93 regulatory factors is mutually inhibitory. The interaction of this network with regulatory hormones likely ensures the orderly progression through insect metamorphosis.
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MEDLINE
Assunto principal:
Proteínas de Drosophila
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Drosophila melanogaster
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Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2022
Tipo de documento:
Article