AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells.

Lin, Cho-Hao; Kuo, Jimmy Chun-Tien; Li, Ding; Koenig, Aaron B; Pan, Alexander; Yan, Pearlly; Bai, Xue-Feng; Lee, Robert J; Ghoshal, Kalpana

Lin, Cho-Hao; Kuo, Jimmy Chun-Tien; Li, Ding; Koenig, Aaron B; Pan, Alexander; Yan, Pearlly; Bai, Xue-Feng; Lee, Robert J; Ghoshal, Kalpana.

Afiliação

Lin CH; Department of Pathology, College of Medicine, Columbus, OH, United States.
Kuo JC; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States.
Li D; Division of Pharmaceutics and Pharmacology, College of Pharmacy, Columbus, OH, United States.
Koenig AB; Division of Pharmaceutics and Pharmacology, College of Pharmacy, Columbus, OH, United States.
Pan A; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States.
Yan P; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States.
Bai XF; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States.
Lee RJ; Department of Pathology, College of Medicine, Columbus, OH, United States.
Ghoshal K; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States.

Front Cell Dev Biol ; 10: 853652, 2022.

Article em En | MEDLINE | ID: mdl-35399501

Palavras-chave

AZD5153; BRD4 (bromodomain-containing protein 4); ChIP-seq; HCC; NAPRT; nanoemulsion

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Front Cell Dev Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos