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More than Just a Monolayer: the Multifaceted Role of Endothelial Cells in the Pathophysiology of Atherosclerosis.
Mussbacher, Marion; Schossleitner, Klaudia; Kral-Pointner, Julia B; Salzmann, Manuel; Schrammel, Astrid; Schmid, Johannes A.
Afiliação
  • Mussbacher M; Department of Pharmacology and Toxicology, University of Graz, Graz, Austria. marion.mussbacher@uni-graz.at.
  • Schossleitner K; Department of Dermatology, Skin and Endothelium Research Division, Medical University of Vienna, Vienna, Austria.
  • Kral-Pointner JB; Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria.
  • Salzmann M; Department of Internal Medicine II/Cardiology, Medical University of Vienna, Vienna, Austria.
  • Schrammel A; Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria.
  • Schmid JA; Department of Internal Medicine II/Cardiology, Medical University of Vienna, Vienna, Austria.
Curr Atheroscler Rep ; 24(6): 483-492, 2022 06.
Article em En | MEDLINE | ID: mdl-35404040
PURPOSE OF THE REVIEW: In this review, we summarize current insights into the versatile roles of endothelial cells in atherogenesis. RECENT FINDINGS: The vascular endothelium represents the first barrier that prevents the entry of lipoproteins and leukocytes into the vessel wall, thereby controlling two key events in the pathogenesis of atherosclerosis. Disturbance of endothelial homeostasis increases vascular permeability, inflammation, and cellular trans-differentiation, which not only promotes the build-up of atherosclerotic plaques but is also involved in life-threatening thromboembolic complications such as plaque rupture and erosion. In this review, we focus on recent findings on endothelial lipoprotein transport, inflammation, cellular transitions, and barrier function. By using cutting-edge technologies such as single-cell sequencing, epigenetics, and cell fate mapping, novel regulatory mechanisms and endothelial cell phenotypes have been discovered, which have not only challenged established concepts of endothelial activation, but have also led to a different view of the disease.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Curr Atheroscler Rep Assunto da revista: ANGIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Áustria

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Curr Atheroscler Rep Assunto da revista: ANGIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Áustria