Combined multivariate statistical and flux balance analyses uncover media bottlenecks to the growth and productivity of Chinese hamster ovary cell cultures.

Yeo, Hock Chuan; Park, Seo-Young; Tan, Tessa; Ng, Say K; Lakshmanan, Meiyappan; Lee, Dong-Yup

Yeo, Hock Chuan; Park, Seo-Young; Tan, Tessa; Ng, Say K; Lakshmanan, Meiyappan; Lee, Dong-Yup.

Afiliação

Yeo HC; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Park SY; School of Chemical Engineering, Sungkyunkwan University, Suwon, Korea.
Tan T; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Ng SK; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Lakshmanan M; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Lee DY; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Biotechnol Bioeng ; 119(7): 1740-1754, 2022 07.

Article em En | MEDLINE | ID: mdl-35435243

Assuntos

Técnicas de Cultura de Células; Animais; Células CHO; Cricetinae; Cricetulus; Meios de Cultura/metabolismo; Humanos; Proteínas Recombinantes/genética

Palavras-chave

CHO cells; flux balance analysis; media reformulation; metabolic bottlenecks; multivariate statistical analysis; systems biotechnology

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Técnicas de Cultura de Células Limite: Animals / Humans Idioma: En Revista: Biotechnol Bioeng Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura

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