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LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation.
Guy, Clifford; Mitrea, Diana M; Chou, Po-Chien; Temirov, Jamshid; Vignali, Kate M; Liu, Xueyan; Zhang, Hui; Kriwacki, Richard; Bruchez, Marcel P; Watkins, Simon C; Workman, Creg J; Vignali, Dario A A.
Afiliação
  • Guy C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Mitrea DM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Chou PC; Dewpoint Therapeutics, Boston, MA, USA.
  • Temirov J; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Vignali KM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Liu X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Zhang H; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Kriwacki R; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
  • Bruchez MP; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Watkins SC; Department of Mathematics, University of New Orleans, New Orleans, LA, USA.
  • Workman CJ; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Vignali DAA; Division of Biostatistics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nat Immunol ; 23(5): 757-767, 2022 05.
Article em En | MEDLINE | ID: mdl-35437325
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Proteína Tirosina Quinase p56(lck) Linfócito-Específica Tipo de estudo: Risk_factors_studies Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Proteína Tirosina Quinase p56(lck) Linfócito-Específica Tipo de estudo: Risk_factors_studies Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos