Emerging ecophenotype: reward anticipation is linked to high-risk behaviours after sexual abuse.
Soc Cogn Affect Neurosci
; 17(11): 1035-1043, 2022 11 02.
Article
em En
| MEDLINE
| ID: mdl-35438797
ABSTRACT
Adolescents frequently engage in high-risk behaviours (HRB) following childhood sexual abuse (CSA). Aberrant reward processes are implicated in HRB, and their underlying fronto-striatal networks are vulnerable to neurodevelopmental changes during adversity representing a promising candidate for understanding links between CSA and HRB. We examined whether fronto-striatal responses during reward anticipation and feedback (i) are altered in depressed adolescents with CSA compared to depressed, non-abused peers and (ii) moderate the relationship between CSA and HRB irrespective of depression. Forty-eight female adolescents {14 with CSA and depression [CSA + major depressive disorder (MDD)]; 17 with MDD but no CSA (MDD); 17 healthy, non-abused controls} completed a monetary reward task during functional magnetic resonance imaging. No differences in fronto-striatal response to reward emerged between CSA + MDD and MDD. Critically, high left nucleus accumbens activation during reward anticipation was associated with greater HRB in CSA + MDD compared to MDD and controls. Low left putamen activation during reward feedback was associated with the absence of HRB in CSA + MDD compared to MDD. Striatal reward responses appear to play a key role in HRB for adolescents with CSA irrespective of depression, providing initial support for a CSA ecophenotype. Such information is pivotal to identify at-risk youth and prevent HRB in adolescents after CSA.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Delitos Sexuais
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Transtorno Depressivo Maior
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
Idioma:
En
Revista:
Soc Cogn Affect Neurosci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido