Fluoride Anion Catalyzed Mukaiyama-Aldol Reaction: Rapid Access to α-Fluoro-ß-hydroxy Esters.
J Org Chem
; 87(10): 6918-6926, 2022 05 20.
Article
em En
| MEDLINE
| ID: mdl-35443775
ABSTRACT
The Mukaiyama-aldol reaction is probably one of the most efficient strategies to prepare synthetically useful ß-hydroxy carbonyl compounds. However, only several reported methods were concerned with the accesses to α-fluoro-ß-hydroxy esters. Herein, we report a protocol for a fluoride anion-mediated Mukaiyama aldol reaction with low catalytic loading in a short reaction time to incorporate fluorine at the α position into ß-hydroxy esters. The method shows good functional-group tolerance and scale-up potential, moreover, is applicable to the late-stage modification of natural products and small molecular drugs.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ésteres
/
Fluoretos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China