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Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism.
Doeppner, Thorsten R; Coman, Cristin; Burdusel, Daiana; Ancuta, Diana-Larisa; Brockmeier, Ulf; Pirici, Daniel Nicolae; Yaoyun, Kuang; Hermann, Dirk M; Popa-Wagner, Aurel.
Afiliação
  • Doeppner TR; Department of Neurology, University Medical Center Göttingen, Göttingen 37075, Germany.
  • Coman C; Research Institute for Health Sciences and Technologies (SABITA), Medipol University, Istanbul, Turkey.
  • Burdusel D; Department of Anatomy and Cell Biology, Medical University of Varna, Varna, Bulgaria.
  • Ancuta DL; Cantacuzino National Medico-Military Institute for Research and Development, Bucharest 050096, Romania.
  • Brockmeier U; Department of Biochemistry, University of Medicine and Pharmacy Craiova, Craiova 200349, Romania.
  • Pirici DN; Cantacuzino National Medico-Military Institute for Research and Development, Bucharest 050096, Romania.
  • Yaoyun K; Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania.
  • Hermann DM; Vascular Neurology and Dementia, Department of Neurology, University of Medicine Essen, Essen 45147, Germany.
  • Popa-Wagner A; Department of Biochemistry, University of Medicine and Pharmacy Craiova, Craiova 200349, Romania.
Aging (Albany NY) ; 14(10): 4195-4210, 2022 05 23.
Article em En | MEDLINE | ID: mdl-35609021
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Autofagia / Cloroquina / Complexo de Endopeptidases do Proteassoma / Glicogenólise / Inibidores de Proteassoma / Longevidade Limite: Animals Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Autofagia / Cloroquina / Complexo de Endopeptidases do Proteassoma / Glicogenólise / Inibidores de Proteassoma / Longevidade Limite: Animals Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha