The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity.
Molecules
; 27(10)2022 May 10.
Article
em En
| MEDLINE
| ID: mdl-35630524
ABSTRACT
In our current investigation, 37 constituents (1-37), including 11 megastigmanes (1-11), 17 flavonoids (12-28) and 9 phenylpropanoids (29-37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus. Among them, compounds 1-3, 12 and 29 were new compounds and their structures were elucidated on the basis of physicochemical evidence and meticulous spectroscopic analysis (NMR, HRESIMS and CD). Compounds 13, 16, 21 and 28 showed moderate inhibitory effect on α-glycosidase inhibitory activities, with IC50 values being in the range of 29.47-54.82 µM and stronger than the positive control (acarbose, 60.01 ± 4.82 µM).
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Alfa-Glucosidases
/
Inibidores de Glicosídeo Hidrolases
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China