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Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure.
De Genst, Erwin; Foo, Kylie S; Xiao, Yao; Rohner, Eduarde; de Vries, Emma; Sohlmér, Jesper; Witman, Nevin; Hidalgo, Alejandro; Kolstad, Terje R S; Louch, William E; Pehrsson, Susanne; Park, Andrew; Ikeda, Yasuhiro; Li, Xidan; Mayr, Lorenz M; Wickson, Kate; Jennbacken, Karin; Hansson, Kenny; Fritsche-Danielson, Regina; Hunt, James; Chien, Kenneth R.
Afiliação
  • De Genst E; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. erwin.degenst@astrazeneca.com.
  • Foo KS; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden. erwin.degenst@astrazeneca.com.
  • Xiao Y; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Rohner E; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • de Vries E; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Sohlmér J; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Witman N; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Hidalgo A; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Kolstad TRS; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Louch WE; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Pehrsson S; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Park A; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Ikeda Y; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Li X; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Mayr LM; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Wickson K; K.G. Jebsen Centre for Cardiac Research, University of Oslo, Oslo, Norway.
  • Jennbacken K; Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Hansson K; K.G. Jebsen Centre for Cardiac Research, University of Oslo, Oslo, Norway.
  • Fritsche-Danielson R; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Hunt J; Biologics Engineering, R&D, AstraZeneca, One MedImmune Way, Gaithersburg, MD, USA.
  • Chien KR; Biologics Engineering, R&D, AstraZeneca, One MedImmune Way, Gaithersburg, MD, USA.
Nat Commun ; 13(1): 3018, 2022 05 31.
Article em En | MEDLINE | ID: mdl-35641497
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido