Gram-selective antibacterial peptide hydrogels.
Biomater Sci
; 10(14): 3831-3844, 2022 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-35678287
ABSTRACT
The human microbiome plays fundamental roles in human health and disease. However, widely used broad-spectrum antibiotics severely disrupt human-related microbial communities, eventually leading to resistant bacteria, posing a growing threat to global medical health. Antimicrobial peptides (AMPs) are promising antimicrobial agents that barely cause bacterial resistance. Excellent broad-spectrum antimicrobial activities have been achieved using hydrogels self-assembled from AMPs, but there is still a lack of AMP hydrogels that can target Gram-positive and Gram-negative bacteria. Herein, several hydrogels self-assembled from AMPs, termed IK1, IK3, and IK4, were designed and synthesized. In vitro antibacterial results indicated that the IK1 and IK4 hydrogels specifically targeted Gram-positive and Gram-negative bacteria, respectively, while the IK3 hydrogel targeted both Gram-positive and Gram-negative bacteria. The desired broad-spectrum or Gram-selective AMP hydrogels are believed to be obtained through the rational design of the hydrophilicity, hydrophobicity, and charge properties of the peptide molecules. Good in vivo Gram-selective antibacterial properties and the ability to promote wound healing have been demonstrated via treating mouse wound models with these AMP hydrogels. We believe that these Gram-selective AMP hydrogels could potentially have important applications in treating common recurring infections.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bactérias Gram-Negativas
/
Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomater Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China