[Impact of combined oral contraceptives and spironolactone on hirsutism and quality of life]. / Contraception Åstroprogestative et spironolactone dans l'hirsutisme: efficacité et impact sur la qualité de vie.
Gynecol Obstet Fertil Senol
; 50(9): 591-599, 2022 09.
Article
em Fr
| MEDLINE
| ID: mdl-35697273
ABSTRACT
OBJECTIVES:
Combined oral contraceptives (COC) and spironolactone are the first and second-line treatments of mild hirsutism, since the use of cyproterone acetate was restricted to the treatment of severe hirsutism by the French guidelines for hyperandrogenism published in May 2020. Because spironolactone was until now barely used in France, the aim of this study was to evaluate the indication, efficacy and impact on quality of life of COC and spironolactone treatments on mild hirsutism in non-menopausal women.METHODS:
This retrospective monocentric study was conducted between June 2020 and October 2021. It included patients with mild hirsutism who received a prescription of COC or/and spironolactone. Modified Ferriman and Gallwey score (FGm) was performed by clinicians and self-rated by patients during the follow-up. Hirsutism-related quality of life was assessed using the Dermatology Life Quality Index (DLQI) and a visual analog scale.RESULTS:
A total of 44 patients were included, but only 30 patients received the treatment for 6 months. 70% of patients were free of side effects. Clinically we observed a decrease of 26% in the FGm score rated by clinicians and patients after 6 months of treatment (P<0,01). This was not correlated with an improvement in quality of life.CONCLUSIONS:
The data collected showed the clinical efficacy of both COC and spironolactone in the treatment of mild hirsutism. These two treatments were well-tolerated. However, the quality of life scores did not improve after 6 months. These treatments should be evaluated after a longer period.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Espironolactona
/
Hirsutismo
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Female
/
Humans
Idioma:
Fr
Revista:
Gynecol Obstet Fertil Senol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França