Quantitative analysis of diffusion weighted imaging in rectal cancer during radiotherapy using a magnetic resonance imaging integrated linear accelerator.
Phys Imaging Radiat Oncol
; 23: 32-37, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35756883
ABSTRACT
Background and purpose:
Magnetic resonance imaging integrated linear accelerator (MR-Linac) platforms enable acquisition of diffusion weighted imaging (DWI) during treatment providing potential information about treatment response. Obtaining DWI on these platforms is technically different from diagnostic magnetic resonance imaging (MRI) scanners. The aim of this project was to determine feasibility of obtaining DWI and calculating apparent diffusion coefficient (ADC) parameters longitudinally in rectal cancer patients on the MR-Linac. Materials andmethods:
Nine patients undergoing treatment on MR-Linac had DWI acquired using b-values 0, 30, 150, 500 s/mm2. Gross tumour volume (GTV) and normal tissue was delineated on DWI throughout treatment and median ADC was calculated using an in-house tool (pyOsirix ®).Results:
Seven out of nine patients were included in the analysis; all demonstrated downstaging at follow-up. A total of 63 out of 70 DWI were analysed (7 excluded due to poor image quality). An increasing trend of ADC median for GTV (1.15 × 10-3 mm2/s interquartile range (IQ) 1.05-1.17 vs 1.59 × 10-3 mm2/s IQ 1.37 - 1.64; p = 0.0156), correlating to treatment response. In comparison ADC median for normal tissue remained the same between first and last fraction (1.61 × 10-3 mm2/s IQ 1.56-1.71 vs 1.67 × 10-3 mm2/s IQ 1.37-2.00; p = 0.9375).Conclusions:
DWI assessment in rectal cancer patients on MR-Linac is feasible. Initial results provide foundations for further studies to determine DWI use for treatment adaptation in rectal cancer.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Phys Imaging Radiat Oncol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido