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Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma.
Mok, Etienne Ho Kit; Leung, Carmen Oi Ning; Zhou, Lei; Lei, Martina Mang Leng; Leung, Hoi Wing; Tong, Man; Wong, Tin Lok; Lau, Eunice Yuen Ting; Ng, Irene Oi Lin; Ding, Jin; Yun, Jing Ping; Yu, Jun; Zhu, Hui Lian; Lin, Chi Ho; Lindholm, Dan; Leung, Kit Sum; Cybulski, Jonathan D; Baker, David M; Ma, Stephanie; Lee, Terence Kin Wah.
Afiliação
  • Mok EHK; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
  • Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
  • Zhou L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
  • Lei MML; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
  • Leung HW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
  • Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
  • Wong TL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
  • Lau EYT; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
  • Ng IOL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
  • Ding J; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
  • Yun JP; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
  • Yu J; Department of Pathology, Sun Yat Sen University Cancer Center, Guangzhou, China.
  • Zhu HL; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
  • Lin CH; School of Public Health, Sun Yat Sen University, Guangzhou, China.
  • Lindholm D; Centre for PanorOmic Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
  • Leung KS; Medicum, Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Cybulski JD; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
  • Baker DM; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong.
  • Ma S; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong.
  • Lee TKW; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong.
Cancer Res ; 82(17): 3102-3115, 2022 09 02.
Article em En | MEDLINE | ID: mdl-35767704
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Colesterol / Carcinoma Hepatocelular / Proteína de Ligação a Elemento Regulador de Esterol 2 / Caspase 3 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hong Kong
Texto completo
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Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Colesterol / Carcinoma Hepatocelular / Proteína de Ligação a Elemento Regulador de Esterol 2 / Caspase 3 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hong Kong