Intraventricular CNS aspergillosis in a patient with prior history of COVID-19: Case report and review of literature.
Ann Med Surg (Lond)
; 80: 104122, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-35821741
ABSTRACT
Introduction and importance Although some immunocompetent patients have developed invasive aspergillosis, the vast majority of cases are seen in immunocompromised patients. COVID-19 infection has been proposed to cause immune dysfunction or suppression, which predisposes patients to fungal co-infections such as mucormycosis and aspergillosis. Case presentation A 58-year-old woman was admitted to the hospital with confusion, dysarthria, and loss of consciousness. The patient had a 1-month prior history of severe COVID-19 infection. A computerized tomography (CT) scan and a magnetic resonance imaging (MRI) revealed an intraventricular lesion with perilesional edema and a significant midline shift, which was initially thought to be an intraventricular tumor. Following a posterior parietal craniotomy, the lesion was resected via a transcortical approach from the posterior parietal region to the right lateral ventricle. Histopathological findings confirmed intraventricular aspergillosis (IVA). The patient was treated with intravenous amphotericin B for two months and discharged with oral variconazole for 4 months. Discussion:
Covid-19 infections can result in- dissemination of fungal diseases such as aspergillosis. As a minor component of cerebral aspergillosis with a poor prognosis, intraventricular aspergillosis necessitates prompt treatment, which includes surgical resection and the administration of anti-fungal medications.Conclusion:
Infection with COVID-19 causes immune dysfunction, which leads to fungal co-infection, including CNS aspergillosis. As a result, all COVID-19 patients who present with acute neurologic symptoms should have CNS aspergillosis considered in their differential diagnosis.
Aspergillosis; CNS; CNS, Central Nervous System; COVID-19; COVID-19, Coronavirus disease 2019; Case report; GCS, Glasgow Coma Scale; IPA, Invasive Pulmonary Aspergillosis; IVA, Intraventricular Aspergillosis; Intraventricular space; SARS-CoV-2; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2
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Bases de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Ann Med Surg (Lond)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Irã