Endo-Lysosomal Two-Pore Channels and Their Protein Partners.

Patel, Sandip; Zissimopoulos, Spyros; Marchant, Jonathan S

Patel, Sandip; Zissimopoulos, Spyros; Marchant, Jonathan S.

Afiliação

Patel S; Department of Cell and Developmental Biology, University College London, London, UK. patel.s@ucl.ac.uk.
Zissimopoulos S; Swansea University Medical School, Institute of Life Science, Swansea, UK.
Marchant JS; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Handb Exp Pharmacol ; 278: 199-214, 2023.

Article em En | MEDLINE | ID: mdl-35902438

ABSTRACT

ABSTRACT

Two-pore channels are ion channels expressed on acidic organelles such as the various vesicles that constitute the endo-lysosomal system. They are permeable to Ca2+ and Na+ and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P2 and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.

Assuntos

Canais de Cálcio; Lisossomos; Humanos; Canais de Cálcio/metabolismo; Lisossomos/metabolismo; Cálcio/metabolismo; Sinalização do Cálcio

Palavras-chave

Ca2+; Endosomes; Lysosomes; NAADP; Na+; PI(3,5)P2; TPCN1; TPCN2

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Canais de Cálcio / Lisossomos Limite: Humans Idioma: En Revista: Handb Exp Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

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