Endo-Lysosomal Two-Pore Channels and Their Protein Partners.
Handb Exp Pharmacol
; 278: 199-214, 2023.
Article
em En
| MEDLINE
| ID: mdl-35902438
ABSTRACT
Two-pore channels are ion channels expressed on acidic organelles such as the various vesicles that constitute the endo-lysosomal system. They are permeable to Ca2+ and Na+ and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P2 and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Canais de Cálcio
/
Lisossomos
Limite:
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido