Penile Erection Induced by Stimulation of Sacral S1/S2 Spinal Root in Cats.
Neuromodulation
; 26(8): 1817-1822, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-35941016
ABSTRACT
OBJECTIVE:
This study aimed at determining whether stimulation of sacral spinal roots can induce penile erection in cats. MATERIALS ANDMETHODS:
In anesthetized cats, a 20-gauge catheter was inserted into the corpus cavernosum to measure the penile pressure. Stimulus pulses (5-80 Hz, 0.2 ms) were applied through bipolar hook electrodes to sacral ventral roots alone or to combined ventral and dorsal roots of a single S1-S3 segment to induce penile pressure increases and penile erection.RESULTS:
Stimulation of the S1 or S2 ventral root at 30 to 40 Hz induced observable penile erection with rigidity and the largest increase (169 ± 11 cmH2O) in penile pressure. Continuous stimulation (10 minutes) of afferent and efferent axons by simultaneous stimulation of the S1 or S2 dorsal and ventral roots at 30 Hz also produced a large increase (190 ± 8 cmH2O) in penile pressure that was sustainable during the entire stimulation period. After a complete spinal cord transection at the T9-T10 level, simultaneous stimulation of the S1 or S2 dorsal and ventral roots induced large (186 ± 9 cmH2O) and sustainable increases in penile pressure.CONCLUSION:
This study indicates the possibility to develop a novel neuromodulation device to restore penile erection after spinal cord injury using a minimally invasive surgical approach to insert a lead electrode through the sacral foramen to stimulate a sacral spinal root.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Ereção Peniana
Limite:
Animals
Idioma:
En
Revista:
Neuromodulation
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos