Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions.

Wong, Felix; Stokes, Jonathan M; Bening, Sarah C; Vidoudez, Charles; Trauger, Sunia A; Collins, James J

Wong, Felix; Stokes, Jonathan M; Bening, Sarah C; Vidoudez, Charles; Trauger, Sunia A; Collins, James J.

Afiliação

Wong F; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Stokes JM; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Bening SC; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vidoudez C; Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA.
Trauger SA; Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA.
Collins JJ; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired

Mol Cell ; 82(18): 3499-3512.e10, 2022 09 15.

Article em En | MEDLINE | ID: mdl-35973427

Assuntos

Antibacterianos; Escherichia coli; Anaerobiose; Antibacterianos/metabolismo; Antibacterianos/farmacologia; Carbono/metabolismo; DNA/metabolismo; Escherichia coli/genética; Escherichia coli/metabolismo; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

anaerobic; antibiotic resistance; antibiotics; antioxidants; macromolecular damage; mass spectrometry; mechanism of action; metabolism; reactive electrophilic species

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Escherichia coli / Antibacterianos Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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