New sulphonamide-peptide hybrid molecules as potential PBP 2a ligands and methicillin resistant <i>Staphylococcus aureus</i> actives.

Ibezim, Akachukwu; Onuku, Raphael; Ottih, Chidalu; Ezeonu, Ifeoma; Onoabedje, Efeturi; Ramanathan, Karuppasamy; Nwodo, Ngozi

New sulphonamide-peptide hybrid molecules as potential PBP 2a ligands and methicillin resistant Staphylococcus aureus actives.

Ibezim, Akachukwu; Onuku, Raphael; Ottih, Chidalu; Ezeonu, Ifeoma; Onoabedje, Efeturi; Ramanathan, Karuppasamy; Nwodo, Ngozi.

Afiliação

Ibezim A; Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, Nigeria.
Onuku R; Department of Biotechnology, Vellore Institute of Technology, Vellore, Tamilnadu, India.
Ottih C; Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, Nigeria.
Ezeonu I; Department of Microbiology, University of Nigeria, Nsukka, Nigeria.
Onoabedje E; Department of Microbiology, University of Nigeria, Nsukka, Nigeria.
Ramanathan K; Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.
Nwodo N; Department of Biotechnology, Vellore Institute of Technology, Vellore, Tamilnadu, India.

J Biomol Struct Dyn ; 41(14): 6684-6694, 2023.

Article em En | MEDLINE | ID: mdl-35975581

Palavras-chave

MRSA; PbP 2a; Sulphonamides; binding mode prediction; molecular docking; molecular dynamics simulation; peptides

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Nigéria