Radiographic changes of mandibular cortical bone in bisphosphonate drug holiday.
J Korean Assoc Oral Maxillofac Surg
; 48(4): 219-224, 2022 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-36043252
ABSTRACT
Objectives:
There have been few studies to date on the residual effect of bisphosphonate. This study investigated the radiographic changes of mandibular cortical thickness upon bisphosphonate drug holiday. Materials andMethods:
This retrospective study includes 36 patients diagnosed with MRONJ (medication-related osteonecrosis of the jaw) at Ajou University Dental Hospital in 2010-2021. All patients stopped taking bisphosphonate under consultation with the prescribing physicians. Panoramic radiographs were taken at the start of discontinuation (T0), 12 months after (T1), and 18 months after (T2) discontinuation of bisphosphonate, respectively. Mental index and panoramic mandibular index were calculated using Ledgerton's method. Paired t-tests were used to analyze differences over time.Results:
The difference in indices (mental index and panoramic mandibular index) between T0 and T1 was not statistically significant (paired t-test, P>0.05). However, the difference in these indices between T1 and T2 was statistically significant (paired t-test, P<0.05).Conclusion:
The cortical thickness of the mandible decreased in the late stage (after 18 months) as observed by panoramic radiograph.
Texto completo:
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Bases de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Korean Assoc Oral Maxillofac Surg
Ano de publicação:
2022
Tipo de documento:
Article