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Liposomal amphotericin B exposure in critically ill patients: a prospective pharmacokinetic study.
Van Daele, Ruth; Wauters, Joost; Elkayal, Omar; Dreesen, Erwin; Debaveye, Yves; Lagrou, Katrien; de Beer, Yvo; Maertens, Johan; Brüggemann, Roger J; Spriet, Isabel.
Afiliação
  • Van Daele R; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven and Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Wauters J; Department of Microbiology, Immunology and Transplantation, KU Leuven and Medical Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Elkayal O; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
  • Dreesen E; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
  • Debaveye Y; Department of Cellular and Molecular Medicine, KU Leuven and Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Lagrou K; Clinical Department of Laboratory Medicine and National Reference Centre for Mycosis, Excellence Centre for Medical Mycology (ECMM), University Hospitals Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
  • de Beer Y; Department of Clinical Pharmacy & Toxicology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
  • Maertens J; Department of Microbiology, Immunology and Transplantation, KU Leuven and Department of Hematology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Brüggemann RJ; Department of Pharmacy and Radboud Institute for Health Sciences, Radboudumc and Center of Expertise in Mycology Radboudumc / CWZ, Radboudumc, 6525 GA Nijmegen, the Netherlands.
  • Spriet I; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven and Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.
Med Mycol ; 60(10)2022 Oct 12.
Article em En | MEDLINE | ID: mdl-36124725
L-AmB is marketed for decades to treat invasive fungal infections; however, not much is known about its exposure. We documented L-AmB exposure in 31 critically ill patients. Although median exposure was similar compared to noncritically ill patients, a considerable variability was observed.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Estado Terminal / Antifúngicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Med Mycol Assunto da revista: MEDICINA VETERINARIA / MICROBIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Estado Terminal / Antifúngicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Med Mycol Assunto da revista: MEDICINA VETERINARIA / MICROBIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica